News You Can Use December 2019

News You Can Use December 2019

Cancer research in the last decade (the 20-teens) revealed a number of important factors that might be mitigated by nutritional intervention.  Statistically, we know that few people die from their original tumor. Since most cancer deaths occur from metastases, it makes sense to study that process, and intervene as soon as possible.  This is not medical advice. It is information to discuss with a qualified health care professional, so that every possible measure can be taken to optimize quality of life and improve the chance for full recovery.

I. Metastasis is driven by inflammation.

A. Foundational paper: Inflaming metastasis. Nature volume 457, pages36–37(2009) Alberto Mantovani, et al.

Full text available at:  https://www.nature.com/articles/457036b

B. Molecular mechanisms

Cell. 2010 Mar 19;140(6):883-99. Immunity, inflammation, and cancer. Grivennikov SI, Greten FR, Karin M.

C. Ben-Neriah, Y., Karin, M. Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol 12, 715–723 (2011)

Based on the latest research, we are creating Nutritional Intervention Capsules (NIC).  Contact Stephen at StephenCherniske108@gmail.com for more information

Each NIC capsule contains: 

à Ingredient 1. Univestin™  150 mg This is a patented plant-based anti-inflammatory compound supported by 7 peer-reviewed, MEDLINE indexed studies including 3 human clinical trials. Moreover, there good evidence that scutellaria baicalensis (the main component of Univestin) has direct anti-cancer activity. 

REFS: 

A. Inhibition of Cancer Cell Proliferation and Prostaglandin E2 Synthesis by Scutellaria Baicalensis. Cancer Research 63, 4037-4043, July 15, 2003 David Y. Zhang, Josephine Wu, et al.

 Full study at:

http://cancerres.aacrjournals.org/cgi/content/full/63/14/4037

B. Nutr J. 2012 Apr 5;11:21. A randomized, double blind, placebo and active comparator controlled pilot study of UP446, a novel dual pathway inhibitor anti-inflammatory agent of botanical origin.

Sampalis JS, Brownell LA.

Full Study at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352039/ 

à Ingredient 2. Curcumin: 75 mg

REFS:

A. Bisht K, Wagner KH, Bulmer AC. Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds. Toxicology. 2009 Nov 10. 

B. Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2

Peter H. Killian, Emanuel Kronski, et al

Carcinogenesis, Volume 33, Issue 12, December 2012, Pages 2507–2519, https://doi.org/10.1093/carcin/bgs312

II. Inositol hexaphosphate shows great promise at all three cancer stages: initiation, progression and metastasis

à Ingredient 3. Inositol hexaphosphate (IP-6) 250 mg

REFS: 

A. J Exp Clin Cancer Res. 2010; 29(1): 12. Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical study Ivan Bačić, Nikica Družijanić, Robert Karlo, Ivan Škifić, and Stjepan Jagić

B. Nutr Cancer. 2006;55(2):109-25. Protection against cancer by dietary IP6 and inositol. Vucenik, Shamsuddin AM.

C.  Molecules. 2017 Oct 3;22(10). pii: E1657. doi: 10.3390/molecules22101657.) Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway. Kapral M et al.  

Full text available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151581/ 

D. Front Pharmacol. 2019; 10: 1172. doi: 10.3389/fphar.2019.01172

PMCID: PMC6798087  PMID: 31680956

Myo-Inositol and Its Derivatives: Their Emerging Role in the Treatment of Human Diseases. Dhani Raj Chhetri

Full text available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798087/  

Additional Nutritional support 

1. Highly varied natural foods diet devoid of sugar 

2. Reduced intake of non-essential fats, and increased intake of Omega-3 fatty acids,  especially EPA and DHA (from fish oil, krill or algae)

REF: Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002 Oct;56(8):365-79.

3.  Alpha Lipoic Acid:  250 mg/d

REFS:

A. Cancer Lett. 2016 Feb 1;371(1):12-9. The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria. Dörsam B, Fahrer J.

B. Biochimica et Biophysica Acta (BBA) – Reviews on Cancer

Volume 1873, Issue 1, January 2020, 188317. Lipoic acid a multi-level molecular inhibitor of tumorigenesis D.Farhat, H.Lincetabce

 

4. Resveratrol: 250 mg twice a week

REF: Alkhalaf M. Resveratrol-induced apoptosis is associated with activation of p53 and inhibition of protein translation in T47D human breast cancer cells. Pharmacology. 2007;80(2-3):134-43.

 

5. CoQ10 300 mg/d

REFS:

A. Biochem Biophys Res Commun. 1994 Mar 30;199(3):1504-8.

Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10.

Lockwood K, Moesgaard S, Folkers K.

B.  Biochem Biophys Res Commun. 1995 Jul 6;212(1):172-7.

Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases.

Lockwood K, Moesgaard S, Yamamoto T, Folkers K.

C. Future Oncol. 2017 May;13(11):1035-1041.  Coenzyme Q10 in breast cancer care. Tafazoli A.

6. Vitamin D3:

Supplementation sufficient to maintain serum 25-hydroxyvitamin D levels between 60 and 100 ng/mL. This may require supplementation of Vitamin D3 from 2,000 to 10,000 iu/day

REF: Cancer Causes & Control. March 2005, Volume 16, Issue 2, pp 83–95| The epidemiology of vitamin D and cancer incidence and mortality: A review (United States)

Edward Giovannucci, et al.

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